Off-Target, On-Point: How Retrogenix® Reduces Risk and Animal Use

In this episode of Sounds of Science, learn how the Retrogenix® platform is reshaping drug development by identifying off-target risks earlier, reducing animal use, and gaining traction with regulators—now as part of the FDA’s ISTAND pilot program. Guests Nick Brown and Mark Aspinall-O’Dea from Charles River Discovery Services share real-world insights on their role in advancing NAMs and supporting safer, faster therapeutic development.

Show Notes 

• Maximize Safer, Targeted Biologic Development with Smarter NAMs-Based Off-Target Screening 
• Paving the Way for Enhanced Drug Development 
• A Status Report on Cell-Based Protein Arrays 
• Retrogenix® Human Protein Library 
• Retrogenix®: The Screen Door of Drug Development 
• Retrogenix® CAR Specificity Testing 
• Charles River Launched New Retrogenix Non-Human Protein Library 

What is Sounds of Science?

Sounds of Science is a monthly podcast about beginnings: how a molecule becomes a drug, how a rodent elucidates a disease pathway, how a horseshoe crab morphs into an infection fighter. The podcast is produced by Eureka, the scientific blog of Charles River, a contract research organization for drug discovery and development. Tune in and begin the journey.